Misperceptions that persons with schizophrenia are violent or dangerous lie at the heart of stigmatizations of the disease. My talk tells the story of how these modern-day American conceptualizations of schizophrenic patients as violent emerged during the civil-rights era of the 1950s-1970s in response to a larger set of conversations about race and racial protest. I integrate institutional, professional, and cultural discourses in order to trace shifts in popular and medical understandings of schizophrenia during the civil rights era-from a disease of white docility to one of “Negro” hostility, and from a disease that was nurtured to one that was feared. The first section tracks the medicalization of race and schizophrenia within a particular institution, the Ionia Hospital for the Criminally Insane. The second section contextualizes the Ionia case histories within shifting psychiatric definitions of schizophrenia. I focus on ways published case studies explicitly connected clinical presentations of African American men with the politics of the civil rights movement in ways that treated aspirations for liberation and civil rights as symptoms of mental illness. Finally, the thirdsection reads shifts in psychiatric nosology within changing American cultural concerns about black masculinity. Triangulating the historical connections between institutional forces, psychiatric practices, and civil-rights politics helps me grapple with some of the seemingly naturalized characteristics of present-day schizophrenia discourse—characteristics that often appear denatured of their explicit connections to race. These include cultural tropes of angry, homeless mentally ill persons, or findings demonstrating that persons with schizophrenia reside in prisons far more often than in psychiatric care facilities.